Mariaclaudia Nicolai

Research assistant

• Application of language models used in Natural Language Processing (NLP) to find machine learning-based solutions by developing tools for microscopy data analysis for the IMMUNEMAP project.

Università della Svizzera italiana (USI), Switzerland

Research trainee

• Evaluation of the resistance mechanism to venetoclax as a consequence of mutations in the regulators of apoptosis BCL2. The research was conducted by studying the binding affinity of the BCL-2 protein family and its inhibitor venetoclax by analyzing protein structure with PyMol and the binding by performing molecular dynamics simulations with Amber.
• Prediction of new mutations of the SARS-CoV-2 spike protein. The research was conducted by analyzing virus structure with PyMol and creating a database of the amino acid sequences of the spike protein from data published on GISAID to train the artificial neural network LSTM and predict new mutations.
• Prediction of T cell receptor (TCR) and antigen binding. The research was conducted by training deep learning BERT and GPT2 models based on the transformer architecture. Models were trained by leveraging either TCR-antigen known or unknown binding specificity amino acid sequences by applying either transfer learning or self-supervised learning.

Institute for Research in Biomedicine (IRB), Università della Svizzera italiana (USI), Switzerland

Research visiting

Paper: Healthcare Android Apps: A Tale of the Customers’ Perspective

• Delft University of Technology (TU Delft)\newline Delft, The Netherlands}} {Investigate the role of user feedback on Android healthcare applications. The research was conducted by analyzing user reviews to classify the comments left for healthcare and non-healthcare apps and by applying the sentiment analysis on these reviews to assess the sentiment between healthcare and non-healthcare apps. Findings from the research presented at the international conference in Tallinn, Estonia.

Delft University of Technology (TU Delft), Delft, The Netherlands

Assistant

• Managing and promoting the activities on social media. Daily cooperation with the manager, creative presentation of new content, handling customer requests.

Foodie Lab, Naples, Italy

Educational intern

• Practice ethical and deontological aspects of the profession of pharmacist. Managing health products. Educating consumers about health prevention and medication usage.

Farmacia Dr. Italiano, Benevento, Italy

Quality control operator

• Collaboration with a research organization responsible for monitoring environmental noise. Testing of electronic devices with precision digital equipment.

Bruitparif, Paris, France

Entrepreneur

Co-founder of the LP Systems B.V.

Company details: LPSystems B.V. designs low-cost professional audio broadcasting equipment

Delft, The Netherlands